What are the signs of warfarin overdose?

What are the signs of warfarin overdose?

Symptoms of overdose may include the following:

• bloody or red, or tarry bowel movements.
• spitting or coughing up blood.
• heavy bleeding with your menstrual period.
• pink, red, or dark brown urine.
• coughing up or vomiting material that looks like coffee grounds.
• small, flat, round red spots under the skin.

What happens when your INR is too high?

The higher your PT or INR, the longer your blood takes to clot. An elevated PT or INR means your blood is taking longer to clot than your healthcare provider believes is healthy for you. When your PT or INR is too high, you have an increased risk of bleeding.

What are the most common complications of an elevated INR with warfarin therapy?

Bleeding is the most serious and common complication of warfarin treatment.

What happens if your blood is too thin on warfarin?

Blood clots can travel through the blood to the brain and cause a stroke. Warfarin ‘thins the blood’ by slowing down the anticoagulation effect of vitamin K, thereby increasing the time it takes blood to clot and reducing the risk of stroke. Taking too much warfain raises the risk of bleeding.

What are the side effects of too much warfarin?

What are the side effects of warfarin?

• Severe bleeding, including heavier than normal menstrual bleeding.
• Red or brown urine.
• Black or bloody stool.
• Severe headache or stomach pain.
• Joint pain, discomfort or swelling, especially after an injury.
• Vomiting of blood or material that looks like coffee grounds.
• Coughing up blood.

What can cause an overdose of warfarin?

Overdose of the oral anticoagulant warfarin (Coumadin), or drug interactions with warfarin, can lead to toxicity. Similarly, toxicity can result from exposure to superwarfarins, which are long-acting anticoagulants used in rodenticides. (See Etiology and Prognosis.)

What is a critical INR level?

[8]For patients who are on anticoagulant therapy, the therapeutic INR ranges between 2.0 to 3.0. INR levels above 4.9 are considered critical values and increase the risk of bleeding.

What is considered dangerously high INR?

INR above 8.0 If the INR is greatly above 8.0 (upwards of 10.0 for a patient with no risk factors for falls or haemorrhage), or the patient is elderly and at risk of a fall, 1-2mg of IV phytomenadione may be considered.

Can you have a stroke while on warfarin?

Stroke can occur in patients on warfarin despite anticoagulation. Patients with a low international normalized ratio (INR) should theoretically be at greater risk for ischemia than those who are therapeutic.

Can warfarin damage your kidneys?

Warfarin is an oral anticoagulant used extensively in clinical practice; However, its side-effect of causing renal damage has been recently detected. The mechanism leading to renal damage is glomerular hemorrhage and red blood cell tubular casts prothrombin time.

How do you reverse warfarin overdose?

The most rapid way of reversing the anticoagulant effect of warfarin is by transfusing fresh frozen plasma. The anticoagulant effect of warfarin is mediated through inhibition of the vitamin K-dependent gamma-carboxylation of coagulation factors II, VII, IX and X.

How do I bring my INR down?

It is most important to eat a healthy, consistent, and balanced diet. Certain foods and dietary supplements have vitamin K. Vitamin K works against warfarin. If you eat more vitamin K, it can decrease your INR.

How do you keep your INR stable?

To keep your INR stable and within the recommended range it is important to: Eat the same number of servings of high Vitamin K foods each week. A good rule is, the greener the plant the higher the Vitamin K level.

Why is my INR suddenly high?

A high INR level can happen when you take warfarin (Coumadin). Warfarin helps prevent blood clots. To do this, it slows the amount of time it takes for your blood to clot. This raises your INR level.

Can you get a blood clot while taking warfarin?

Yes. Medications that are commonly called blood thinners — such as aspirin, warfarin (Coumadin, Jantoven), dabigatran (Pradaxa), rivaroxaban (Xarelto), apixaban (Eliquis) and heparin — significantly decrease your risk of blood clotting, but will not decrease the risk to zero.

Can you have a stroke if you are on warfarin?